Dimethyl Sulfate

Molecular formula: C2H6SO4

【 Molecular Weight 】 137.18

CA login number: 77-78-1

[Abbreviation and alias] Methyl Sulfate, also known as methyl sulfate.

【 Physical Properties 】 Colorless liquid, mp -38.1 ° C, bp 188 ° C, d 1.33g/mL. Dissolved in methanol, ethanol, ether, dichloromethane, and acetone, it decomposes slowly in cold water and rapidly at temperatures exceeding 18 ° C.

Both domestic and foreign reagent companies sell [Preparation and Products].

【 Precautions 】 It is highly toxic and can be absorbed through the skin. It must be operated and used in a fume hood.

Dimethyl sulfate is an excellent methylation reagent that can be used as a methylation reagent for phenols, amines, and thiols. The transfer of methyl groups is through the Sn2 reaction, and the transfer of one methyl group is easier than the second one. Due to its high toxicity, dimethyl sulfate is now being replaced by other low toxicity methylation reagents.